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PICTURE
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Neuropsychology of cognitive impairment and central nervous system degenerative diseases

Sector ERC

SH4_3 - Neuropsychology and clinical psychology
SH4_4 - Cognitive and experimental psychology: perception, action, and higher cognitive processes

Activity

Research Topics

Metacognitive executive dysfunctions in neurodegenerative diseases

The study of executive dysfunctions in neurocognitive disorders and degenerative pathologies of the CNS is an important topic that is explored in detail. In the research group (RG) the variables of interest are taken into consideration according to a convergent perspective at a neuropsychological level of explanation. Our group has achieved important results, in line with this neurocognitive approach, published in the major scientific journal of the sector. The originality of the RG is given by the use of a multidimensional model. It is important to underline that an analysis of neuropsychological dysfunctions related to ventromesial prefrontal structures is also provided, through clinical batteries and through neuroimaging techniques.

  1. Amanzio, M., Palermo, S., Zucca, M., Rosato, R., Rubino, E., Leotta, D., Bartoli, M., & Rainero, I. [2018]. Neuropsychological correlates of instrumental activities of daily living in neurocognitive disorders: a possible role for executive dysfunction and mood changes. International psychogeriatrics, 30(12): 1871-1881.
  2. Palermo, S., Lopiano, L., Morese, R., Zibetti, M., Romagnolo, A., Stanziano, M., Rizzone, M.G., Geminiani, G.C., Valentini, M.C., & Amanzio, M. [2018]. Role of the cingulate cortex in dyskinesias-reduced-self-awareness: an fMRI study on Parkinson’s disease patients. Frontiers in psychology, 9: 1765.
  3. Palermo, S., Lopiano, L., Zibetti, M., Rosato, R., Leotta, D., & Amanzio, M. [2017]. A novel framework for understanding reduced awareness of dyskinesias in Parkinson's Disease. Parkinsonism & related disorders, 39: 58-63.
  4. Amanzio, M., D'Agata, F., Palermo, S., Rubino, E., Zucca, M., Galati, A., Pinessi, L., Castellano, G., Rainero, I. [2017]. Corrigendum to "Neural correlates of reduced awareness in instrumental activities of daily living in frontotemporal dementia" [Experimental Gerontology 83 (2016) 158-164]. Experimental Gerontolology, 96:164-165.
  5. Amanzio, M., D’Agata, F., Palermo, S., Rubino, E., Zucca, M., Galati, A., Pinessi, L., Castellano, G., Rainero, I. [2016]. Neural correlates of reduced awareness in instrumental activities of daily living in frontotemporal dementia. Experimental Gerontology, 83: 158-164.

 

The Placebo and Nocebo Effects

The PI has achieved important results in the placebo-nocebo field. The study of placebo analgesia (PA) in patients with neurodegenerative diseases, through the analysis of neuropsychological and neurophysiological elements modulated by the expectation mechanism, has important clinical implications. A patient's expectation of improvement may affect the outcome of the placebo response. The paucity of data and the severity of neurodegenerative diseases justify the need to start specific projects (see as an example our study: Exp Gerontol. 2019 Apr; 118: 106-116). Placebo treatment in randomized clinical trials can also have negative effects (nocebo) associated with an expectation of worsening the symptomatic picture, in terms of side effects. Finally, meta-analysis techniques are conducted to review the data published by the literature on the placebo and nocebo effect.

  1. Palermo, S., Rainero, I., Stanziano, M., Vase, L., D'Agata, F., Rubino, E., Fonio, P., Sardanelli, F. & Amanzio, M. [2019]. A novel neurocognitive approach for placebo analgesia in neurocognitive disorders. Experimental gerontology, 118: 106-116.
  2. Palermo, S., Giovannelli, F., Bartoli, M., & Amanzio, M. [2019]. Are patients with Schizophrenia Spectrum Disorders more prone to manifest nocebo-like-effects? A meta-analysis of adverse events in placebo groups of double-blind antipsychotic trials. Frontiers in pharmacology 10: 502.
  3. Amanzio, M., Palermo, S., Skyt, I., Vase, L. [2016]. Lessons Learned from Nocebo Effects in Clinical Trials for Pain Conditions and Neurodegenerative Disorders. Journal of Clinical Psychopharmacology 36: 475-482.
  4. Amanzio, M. [2016]. The role of cognitive impairment in the placebo and nocebo effects (Book Chapter). An Introduction to Pain and its Relation to Nervous System Disorders, 373-386.
  5. Amanzio, M. [2016]. Nocebo and Pain (Book Chapter). The Neuroscience of Pain, Stress and Emotion: Psychological and Clinical Implications, 117-131.
  6. Amanzio, M. [2015]. Nocebo effects and psychotropic drug action. Editorial for Expert Review of Clinical Pharmacology 8(2):159-61.
  7. Vase, L., Amanzio, M., Price, D.D. [2015]. Nocebo vs. placebo: the challenges of trial design in analgesia research. Clinical Pharmacology & Therapeutics, 97:143-50.

     

Pain processing in patients with neurocognitive disorders

Pain processing and its correct assessment are important aspects to be carefully evaluated in patients with neurodegenerative disorders, in order to increase the response to analgesic drugs and their quality of life.

  1. de Waal, M. W., van Dalen‐Kok, A. H., de Vet, H. C., Gimenez‐Llort, L., Konstantinovic, L., de Tommaso, M., ... & Lobbezoo, F. [2019]. Observational pain assessment in older persons with dementia in four countries: observer agreement of items and factor structure of the Pain Assessment in Impaired Cognition. European Journal of Pain
  2. Amanzio, M. [2016]. Nocebo and Pain (Book Chapter). The Neuroscience of Pain, Stress and Emotion: Psychological and Clinical Implications, 117-131.
  3. Defrin, R., Amanzio, M., de Tommaso, M., Dimova, V., Filipovic, S., Finn, D. P., ... & Oosterman, J. M. [2015]. Experimental pain processing in individuals with cognitive impairment: current state of the science. Pain, 156, 1396-1408.
  4. Palermo, S., Benedetti, F., Costa, T., Amanzio, M. [2015] Pain anticipation: An activation likelihood estimation meta-analysis of brain imaging studies. Human Brain Mapping, 36:1648-61.

 

Frailty in elderly people

 The present topic is based on the construction of new frailty indexes related to biomarkers and a cognitive / behavioral involution in subjects with MCI, major neurocognitive disorders and in normal cognitive aging. The concept of frailty denotes a loss of biological reserves in terms of: energy, physical, cognitive and health status. This puts frailty subjects with neurodegenerative diseases at a greater risk of negative outcomes. Through this theme it will be shown how the measurement of frailty is important for primary prevention, early diagnosis, cognitive impairment and prognosis.

  1. Amanzio, M., Palermo, S., Zucca, M., Rosato, R., Rubino, E., Leotta, D., Bartoli, M., & Rainero, I. [2017]. Neuropsychological correlates of pre-Frailty in neurocognitive disorders: a possible role for metacognitive dysfunction and mood changes. Frontiers in medicine, 4: 199.

 

Future research lines

  1. Validation of prognostic and diagnostic indicators of frailty aimed at better understanding neurocognitive disorders
  2. Role of metacognitive executive dysfunctions in normal cognitive aging and neurocognitive disorders
  3. Legal capacity of the elderly in normal cognitive ageing and with neurocognitive disorders
  4. Executive Dysfunctions in persistent offenders

 

National and international scientific collaborations

European Innovation Partnership on Active and Healthy Ageing. Action Group A3 on Functional decline and Frailty. Synergy Group on "Information technology and adherence in ageing population with chronic diseases and polypharmacy".

VASE LENE – associate Professor, Aarhus University, Denmark. Department of Psychology e Danish Pain centre (SSD: MPSI_02)

Co-autorship Publications:

  1. Palermo, S., Rainero, I., Stanziano, M., Vase, L., D'Agata, F., Rubino, E., Fonio, P., Sardanelli, F. & Amanzio, M. [2019]. A novel neurocognitive approach for placebo analgesia in neurocognitive disorders. Experimental gerontology, 118: 106-116.
  2. Amanzio, M., Palermo, S., Skyt, I., Vase, L. [2016]. Lessons Learned from Nocebo Effects in Clinical Trials for Pain Conditions and Neurodegenerative Disorders. Journal of Clinical Psychopharmacology 36: 475-482.
  3. Defrin, R., Amanzio, M., de Tommaso, M., Dimova, V., Filipovic, S., Finn, D.P., Gimenez-Llort, L., Invitto, S., Jensen-Dahm, C., Lautenbacher, S., Oosterman, J.M., Petrini, L., Pick, C.G., Pickering, G., Vase, L., Kunz, M. [2015]. Experimental pain processing in individuals with cognitive impairment: current state of the science. Pain 156(8):1396-408.
  4. Vase, L., Amanzio, M., Price, D. [2015]. Nocebo versus Placebo: The Challenges of Trial Design in Analgesia Research. Clinical Pharmacology and Therapeutics 97(2):143-50.
  5. Petersen, G.L., Finnerup, N.B., Colloca, L., Amanzio, M., Price, D.D., Staehelin Jensen, T., Vase, L. [2014]. The magnitude of nocebo effects in pain: A meta-analysis. Pain 155(8):1426-1434.

RAINERO INNOCENZO - Full Professor, Department of Neurosciences. 1-U Neurology, City of Health and Science of Turin (SSD: MED/26).

Co-autorship Publications:

  1. Palermo, S., Rainero, I., Stanziano, M., Vase, L., D'Agata, F., Rubino, E., Fonio, P., Sardanelli, F. & Amanzio, M. [2019]. A novel neurocognitive approach for placebo analgesia in neurocognitive disorders. Experimental gerontology, 118: 106-116.
  2. Amanzio, M., Palermo, S., Zucca, M., Rosato, R., Rubino, E., Leotta, D., Bartoli, M., & Rainero, I. [2018]. Neuropsychological correlates of instrumental activities of daily living in neurocognitive disorders: a possible role for executive dysfunction and mood changes. International psychogeriatrics, 30(12): 1871-1881.
  3. Amanzio, M., Palermo, S., Zucca, M., Rosato, R., Rubino, E., Leotta, D., Bartoli, M., & Rainero, I. [2017]. Neuropsychological correlates of pre-Frailty in neurocognitive disorders: a possible role for metacognitive dysfunction and mood changes. Frontiers in medicine, 4: 199.
  4. Amanzio, M., D’Agata, F., Palermo, S., Rubino, E., Zucca, M., Galati, A., Pinessi, L., Castellano, G., Rainero, I. [2016]. Neural correlates of reduced awareness in instrumental activities of daily living in frontotemporal dementia. Experimental Gerontology, 83: 158-164.

LEOTTA DANIELA - Asl TO1. Medical director and Chief of the Department of Neurology, Martini Hospital, Turin (IT).

Co-autorship Publications:

  1. Amanzio, M., Palermo, S., Zucca, M., Rosato, R., Rubino, E., Leotta, D., Bartoli, M., & Rainero, I. [2018]. Neuropsychological correlates of instrumental activities of daily living in neurocognitive disorders: a possible role for executive dysfunction and mood changes. International psychogeriatrics, 30(12): 1871-1881.
  2. Amanzio, M., Palermo, S., Zucca, M., Rosato, R., Rubino, E., Leotta, D., Bartoli, M., & Rainero, I. [2017]. Neuropsychological correlates of pre-Frailty in neurocognitive disorders: a possible role for metacognitive dysfunction and mood changes. Frontiers in medicine, 4: 199.
  3. Amanzio, M., Palermo, S., Zibetti, M., Leotta, D., Rosato, R., Geminiani, G., Lopiano, L. [2014]. Self-unawareness of Levodopa induced dyskinesias in patients with Parkinson’s Disease. Brain and Cognition 90C:135-141.
  4. Palermo, S., Leotta, D., Bongioanni, M., Amanzio, M. [2014]. Unawareness of deficits in ischemic injury: Role of the Cingulate Cortex. NeuroCase 20 (5): 540-555.

 

Research equipment 

Neuropsychological testing, instrumentation for evaluating the variables of interest and software used by the Department and by CRT loans at the UNITRE-Turin research and development lab

 

Research projects and relevant activities related to the RPG:

M.A. is currently the coordinator of the Commitment selected by the European Union, inserted within the Partnership on Healthy and Active Aging, EIP-AHA. M.A. is part of the Action Group A3 "Functional Decline and Frailty". She is also involved by  in theEIP-AHA Synergy-Action-Group: "Information technology and adherence in aging population with chronic diseases and polypharmacy". M.A. was previously involved in the Management Committee of the European-COST-Action-TD-1005 call funded with European funds addressed to elderly people with cognitive impairment and painful symptoms (PAIC, Workgroup-4).
The research lines on healthy and active aging have also been previously funded by the CRT-Foundation (GAIA-MENTE and GAIA-MENTE 2). The CRT-foundation has recently funded GAIA-MENTE 3 for the study of subjects with mild cognitive impairment and the GAIA-MENTE-4 project for the support of the activities of the UNITRE Turin "formation, training, research and development laboratory".
The PI currently directs the scientific magazine Frontiers in Psychology - Section: Neuropsychology - as Chief Editor.

 

ERC sectors in line with research topics:

SH4_3 - Neuropsychology and clinical psychology

SH4_4 - Cognitive and experimental psychology: perception, action, and higher cognitive processes

LS5_1 - Neuroanatomy and neurophysiology

LS5_3 - Neurochemistry and neuropharmacology

LS5_5 - Mechanisms of pain

LS5_11 - Neurological disorders

 

University Research Forum:

NEUROPSYCHOLOGICAL ASSESSMENT OF NEUROCOGNITIVE DISORDERS AND ACTIVE AGEING: PANDORA

http://frida.unito.it/wn_pages/percorso.php/412_la-mente-umana-e-la-sua-complessit-educazione-e-linguaggio/2807/

 

Publications

Amanzio M, Palermo S. (2019) Pain Anticipation and Nocebo-Related Responses: A Descriptive Mini-Review of Functional Neuroimaging Studies in Normal Subjects and Precious Hints on Pain Processing in the Context of Neurodegenerative Disorders. Frontiers in pharmacology 10 969 [DOI  PMID]

de Waal MWM, van Dalen-Kok AH, de Vet HCW, Gimenez-Llort L, Konstantinovic L, de Tommaso M, Fischer T, Lukas A, Kunz M, Lautenbacher S, Lobbezoo F, McGuire BE, van der Steen JT, Achterberg WP. (2019) Observational pain assessment in older persons with dementia in four countries: observer agreement of items and factor structure of the Pain Assessment in Impaired Cognition. European journal of pain (London, England) [DOI  PMID]

Palermo S, Giovannelli F, Bartoli M, Amanzio M. (2019) Are Patients With Schizophrenia Spectrum Disorders More Prone to Manifest Nocebo-Like-Effects? A Meta-Analysis of Adverse Events in Placebo Groups of Double-Blind Antipsychotic Trials. Frontiers in pharmacology 10 502 [DOI  PMID]

Palermo S, Rainero I, Stanziano M, Vase L, D'Agata F, Rubino E, Fonio P, Sardanelli F, Amanzio M. (2019) A novel neurocognitive approach for placebo analgesia in neurocognitive disorders. Experimental gerontology 118 106-116 [DOI  PMID]

Palermo S, Lopiano L, Morese R, Zibetti M, Romagnolo A, Stanziano M, Rizzone MG, Geminiani GC, Valentini MC, Amanzio M. (2018) Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson's Disease Patients. Frontiers in psychology 9 1765 [DOI  PMID]

Amanzio M, Palermo S, Zucca M, Rosato R, Rubino E, Leotta D, Bartoli M, Rainero I. (2018) Neuropsychological correlates of instrumental activities of daily living in neurocognitive disorders: a possible role for executive dysfunction and mood changes. International psychogeriatrics 30(12) 1871-1881 [DOI  PMID]

Amanzio M, Palermo S, Zucca M, Rosato R, Rubino E, Leotta D, Bartoli M, Rainero I. (2017) Neuropsychological Correlates of Pre-Frailty in Neurocognitive Disorders: A Possible Role for Metacognitive Dysfunction and Mood Changes. Frontiers in medicine 4 199 [DOI  PMID]

Amanzio M, D'Agata F, Palermo S, Rubino E, Zucca M, Galati A, Pinessi L, Castellano G, Rainero I. (2017) Corrigendum to "Neural correlates of reduced awareness in instrumental activities of daily living in frontotemporal dementia" [Exp. Gerontol. 83 (2016) 158-164]. Experimental gerontology 96 164-165 [DOI  PMID]

Palermo S, Lopiano L, Zibetti M, Rosato R, Leotta D, Amanzio M. (2017) A novel framework for understanding reduced awareness of dyskinesias in Parkinson's Disease. Parkinsonism & related disorders 39 58-63 [DOI  PMID]

Amanzio M, Palermo S, Skyt I, Vase L. (2016) Lessons Learned From Nocebo Effects in Clinical Trials for Pain Conditions and Neurodegenerative Disorders. Journal of clinical psychopharmacology 36(5) 475-82 [DOI  PMID]

Amanzio M, D'Agata F, Palermo S, Rubino E, Zucca M, Galati A, Pinessi L, Castellano G, Rainero I. (2016) Neural correlates of reduced awareness in instrumental activities of daily living in frontotemporal dementia. Experimental gerontology 83 158-64 [DOI  PMID]

Defrin R, Amanzio M, de Tommaso M, Dimova V, Filipovic S, Finn DP, Gimenez-Llort L, Invitto S, Jensen-Dahm C, Lautenbacher S, Oosterman JM, Petrini L, Pick CG, Pickering G, Vase L, Kunz M. (2015) Experimental pain processing in individuals with cognitive impairment: current state of the science. Pain 156(8) 1396-408 [DOI  PMID]

Vase L, Amanzio M, Price DD. (2015) Nocebo vs. placebo: the challenges of trial design in analgesia research. Clinical pharmacology and therapeutics 97(2) 143-50 [DOI  PMID]

Palermo S, Benedetti F, Costa T, Amanzio M. (2015) Pain anticipation: an activation likelihood estimation meta-analysis of brain imaging studies. Human brain mapping 36(5) 1648-61 [DOI  PMID]

Amanzio M. (2015) Nocebo effects and psychotropic drug action. Expert review of clinical pharmacology 8(2) 159-61 [DOI  PMID]

Amanzio M, Palermo S, Zibetti M, Leotta D, Rosato R, Geminiani G, Lopiano L. (2014) Self-unawareness of levodopa induced dyskinesias in patients with Parkinson's disease. Brain and cognition 90 135-41 [DOI  PMID]

Palermo S, Cauda F, Costa T, Duca S, Gallino G, Geminiani G, Keller R, Amanzio M. (2015) Unawareness of bipolar disorder: the role of the cingulate cortex. Neurocase 21(4) 438-47 [DOI  PMID]

Petersen GL, Finnerup NB, Colloca L, Amanzio M, Price DD, Jensen TS, Vase L. (2014) The magnitude of nocebo effects in pain: a meta-analysis. Pain 155(8) 1426-34 [DOI  PMID]

Palermo S, Leotta D, Bongioanni MR, Amanzio M. (2014) Unawareness of deficits in ischemic injury: role of the cingulate cortex. Neurocase 20(5) 540-55 [DOI  PMID]

Benedetti F, Amanzio M. (2013) Mechanisms of the placebo response. Pulmonary pharmacology & therapeutics 26(5) 520-3 [DOI  PMID]

Amanzio M, Vase L, Leotta D, Miceli R, Palermo S, Geminiani G. (2013) Impaired awareness of deficits in Alzheimer's disease: the role of everyday executive dysfunction. Journal of the International Neuropsychological Society : JINS 19(1) 63-72 [DOI  PMID]

Cauda F, Torta DM, Sacco K, Geda E, D'Agata F, Costa T, Duca S, Geminiani G, Amanzio M. (2012) Shared "core" areas between the pain and other task-related networks. PloS one 7(8) e41929 [DOI  PMID]

Amanzio M, Benedetti F, Vase L. (2012) A systematic review of adverse events in the placebo arm of donepezil trials: the role of cognitive impairment. International psychogeriatrics 24(5) 698-707 [DOI  PMID]

Amanzio M, Benedetti F, Porro CA, Palermo S, Cauda F. (2013) Activation likelihood estimation meta-analysis of brain correlates of placebo analgesia in human experimental pain. Human brain mapping 34(3) 738-52 [DOI  PMID]

Benedetti F, Amanzio M, Rosato R, Blanchard C. (2011) Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nature medicine 17(10) 1228-30 [DOI  PMID]

Benedetti F, Amanzio M. (2011) The placebo response: how words and rituals change the patient's brain. Patient education and counseling 84(3) 413-9 [DOI  PMID]

Amanzio M, Torta DM, Sacco K, Cauda F, D'Agata F, Duca S, Leotta D, Palermo S, Geminiani GC. (2011) Unawareness of deficits in Alzheimer's disease: role of the cingulate cortex. Brain : a journal of neurology 134(Pt 4) 1061-76 [DOI  PMID]

Amanzio M. (2011) Do we need a new procedure for the assessment of adverse events in anti-migraine clinical trials? Recent patents on CNS drug discovery 6(1) 41-7 [PMID]

Benedetti F, Amanzio M, Thoen W. (2011) Disruption of opioid-induced placebo responses by activation of cholecystokinin type-2 receptors. Psychopharmacology 213(4) 791-7 [DOI  PMID]

Amanzio M, Monteverdi S, Giordano A, Soliveri P, Filippi P, Geminiani G. (2010) Impaired awareness of movement disorders in Parkinson's disease. Brain and cognition 72(3) 337-46 [DOI  PMID]

Amanzio M, Corazzini LL, Vase L, Benedetti F. (2009) A systematic review of adverse events in placebo groups of anti-migraine clinical trials. Pain 146(3) 261-9 [DOI  PMID]

Amanzio M, Geminiani G, Leotta D, Cappa S. (2008) Metaphor comprehension in Alzheimer's disease: novelty matters. Brain and language 107(1) 1-10 [DOI  PMID]

Benedetti F, Amanzio M, Vighetti S, Asteggiano G. (2006) The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. The Journal of neuroscience : the official journal of the Society for Neuroscience 26(46) 12014-22 [DOI  PMID]

Rainero I, Amanzio M, Vighetti S, Bergamasco B, Pinessi L, Benedetti F. (2001) Quantitative EEG responses to ischaemic arm stress in migraine. Cephalalgia : an international journal of headache 21(3) 224-9 [PMID]

Pollo A, Amanzio M, Arslanian A, Casadio C, Maggi G, Benedetti F. (2001) Response expectancies in placebo analgesia and their clinical relevance. Pain 93(1) 77-84 [PMID]

Amanzio M, Pollo A, Maggi G, Benedetti F. (2001) Response variability to analgesics: a role for non-specific activation of endogenous opioids. Pain 90(3) 205-15 [PMID]

Benedetti F, Arduino C, Amanzio M. (1999) Somatotopic activation of opioid systems by target-directed expectations of analgesia. The Journal of neuroscience : the official journal of the Society for Neuroscience 19(9) 3639-48 [PMID]

Benedetti F, Amanzio M, Baldi S, Casadio C, Maggi G. (1999) Inducing placebo respiratory depressant responses in humans via opioid receptors. The European journal of neuroscience 11(2) 625-31 [PMID]

Amanzio M, Benedetti F. (1999) Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. The Journal of neuroscience : the official journal of the Society for Neuroscience 19(1) 484-94 [PMID]

Benedetti F, Amanzio M, Baldi S, Casadio C, Cavallo A, Mancuso M, Ruffini E, Oliaro A, Maggi G. (1998) The specific effects of prior opioid exposure on placebo analgesia and placebo respiratory depression. Pain 75(2-3) 313-9 [PMID]

Benedetti F, Vighetti S, Ricco C, Amanzio M, Bergamasco L, Casadio C, Cianci R, Giobbe R, Oliaro A, Bergamasco B, Maggi G. (1998) Neurophysiologic assessment of nerve impairment in posterolateral and muscle-sparing thoracotomy. The Journal of thoracic and cardiovascular surgery 115(4) 841-7 [DOI  PMID]

Benedetti F, Vighetti S, Amanzio M, Casadio C, Oliaro A, Bergamasco B, Maggi G. (1998) Dose-response relationship of opioids in nociceptive and neuropathic postoperative pain. Pain 74(2-3) 205-11 [PMID]

Benedetti F, Amanzio M, Casadio C, Cavallo A, Cianci R, Giobbe R, Mancuso M, Ruffini E, Maggi G. (1997) Postthoracoscopy pain: is TENS the answer? The Annals of thoracic surgery 64(3) 890-1 [PMID]

Benedetti F, Amanzio M, Casadio C, Filosso PL, Molinatti M, Oliaro A, Pischedda F, Maggi G. (1997) Postoperative pain and superficial abdominal reflexes after posterolateral thoracotomy. The Annals of thoracic surgery 64(1) 207-10 [PMID]

Benedetti F, Amanzio M, Casadio C, Oliaro A, Maggi G. (1997) Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. Pain 71(2) 135-40 [PMID]

Benedetti F, Amanzio M. (1997) The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin. Progress in neurobiology 52(2) 109-25 [PMID]

Benedetti F, Amanzio M, Casadio C, Cavallo A, Cianci R, Giobbe R, Mancuso M, Ruffini E, Maggi G. (1997) Control of postoperative pain by transcutaneous electrical nerve stimulation after thoracic operations. The Annals of thoracic surgery 63(3) 773-6 [PMID]

Benedetti F, Amanzio M, Maggi G. (1995) Potentiation of placebo analgesia by proglumide. Lancet (London, England) 346(8984) 1231 [PMID]

Last update: 03/10/2019 13:50
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